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目的分析抗酸剂、抑酸剂、胃动力药、黏膜保护剂治疗反流性食管炎的临床疗效。方法收集经平顶山煤业医疗集团八矿医院收治的36例HP阴性的反流性食管炎患者,随机分为两组。治疗组接受硫酸铝、奥美拉唑、吗丁啉、果胶铋联合用药治疗,而对照组患者接受以上四种药中的单一药物治疗。治疗8周后观察其病情变化及临床恢复情况,并通过食管pH值及压力测定,比较各指标情况。结果两组经过8周治疗后,治疗组患者临床症状(胸骨后烧灼、反酸、吞咽障碍等症状)明显改善,食管pH值及压力测定均明显改善(P<0.05)。结论抗酸剂、抑酸剂、胃动力药、黏膜保护剂联合用药是治疗反流性食管炎的有效方法 。
Objective To analyze the clinical effects of antacids, acid-suppressing agents, gastric motive agents and mucosal protective agents in the treatment of reflux esophagitis. Methods Thirty-six patients with HP-negative reflux esophagitis treated by Pingdingshan Coal Medical Group 8 Hospital were collected and randomly divided into two groups. The treatment group received aluminum sulfate, omeprazole, domperidone, pectin bismuth combination therapy, while the control group of patients receiving more than one of the four drugs in a single drug treatment. Eight weeks after the treatment, the changes of the disease and the clinical recovery were observed. The esophageal pH value and pressure were measured to compare the indexes. Results After 8 weeks of treatment, the clinical symptoms (post-sternal cauterization, acid reflux, dysphagia and other symptoms) of the treatment group were significantly improved. The esophageal pH value and pressure were significantly improved (P <0.05). Conclusion Antacids, antacids, gastric motility agents and mucosal protective agents are effective methods for the treatment of reflux esophagitis.