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目的 分析CD64指数与慢性阻塞性肺病急性加重期(AECOPD)的相关性,探讨CD64指数对AECOPD早期诊断的价值.方法 收集2016年1月-2017年5月来本院急诊科就诊的AECOPD患者52例,急性加重期组中48例经治疗转为稳定期,4例死亡,以同期来自本院体检中心的各项检查指标均正常健康体检者35例为健康对照组,检测入院2h内患者及健康体检者CD64指数、C-反应蛋白(CRP)水平、动脉血气分析等指标的变化,并进行肺功能检查.结果 与健康对照组相比,AECOPD与稳定期CD64指数均明显升高,差异有统计学意义(P＜0.01);COPD加重期CD64与PaO2 、FEV1呈线性负相关(r值分别为-0.64、-0.76,P＜0.01);与PaCO2、CRP呈线性正相关(r值分别为0.53、0.88,P＜0.01).结论 CD64指数与AECOPD肺功能损伤程度有关,CD64指数可以有效地评估患者病情严重程度.“,”Objective To analyze the correlation between CD64 index and acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and to explore the value of CD64 index in the early diagnosis of AECOPD.Methods A total of 52 AECOPD patients were enrolled in our emergency department from January 2016 to May 2017.48 patients in the acute exacerbation group were treated with stable stage and 4 patients died.35 cases of normal healthy subjects were collected as the healthy control group,CD64 index,C-reactive protein levels(CRP),arterial blood gas analysis were detected after 2 h admission in patients and healthy subjects.Results There was statistical significance on the difference between AECOPD and stable CD64,compared with the control group (P ＜ 0.05).CD64 index of AECOPD was positively correlated with PaO2 and CRP level (r =-0.64,r =-0.76,P ＜ 0.01);and there was a positive correlation between PaO2 and CRP(r =0.53,r =0.88,P ＜ 0.01).Conclusion CD64 index is related to the degree of lung injury in AECOPD,which can effectively assess the severity of the disease.