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结肠直肠手术后最常见的化脓性併发症是需氧性和厌氧性肠道细菌的混合感染,其中病菌以大肠杆菌和脆弱类杆菌居最多。在感染早期,兼性厌氧菌,尤以大肠杆菌起主要作用;而在脓肿形成阶段,则为厌氧菌,主要为脆弱类杆菌起作用。因此,在结肠直肠外科中,预防性应用的抗菌素必需能对抗需氧和厌氧这两类肠道细菌。甲氧噻吩头孢菌素(Cefoxitin)是一种半合成的头孢菌素。在体外试验,各种兼性厌氧革兰氏阴性和阳性菌,厌氧细菌,包括脆弱类杆菌均对甲氧噻吩头孢菌素敏感。本文旨在研究单独应用甲氧噻吩头孢菌素及与丙磺舒合并应用在结肠直肠外科中的作用。
The most common suppurative complication after colorectal surgery is a mixed infection of aerobic and anaerobic gut bacteria, with the largest number of bacteria being Escherichia coli and Bacteroides fragilis. In the early stages of infection, facultative anaerobes, especially E. coli play a major role; in the abscess formation stage, the anaerobic bacteria, mainly Bacteroides fragilis role. Therefore, in colorectal surgery, prophylactic antibiotics must be able to fight both aerobic and anaerobic intestinal bacteria. Cefoxitin is a semisynthetic cephalosporin. In in vitro tests, various facultative anaerobic Gram-negative and positive bacteria, anaerobic bacteria, including Bacteroides fragilis were susceptible to cefotaxime. This article aims to study the separate application of trimethoprim cephalosporin and probenecid combined with the role in colorectal surgery.