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目的探讨青岛市女性卵巢早衰(POF)发生情况及危险因素,为临床防治POF提供指导。方法选取2015年1-12月于青岛市第三人民医院就诊的120例POF患者为研究对象(POF组),另选取120例性激素检查正常、月经正常及年龄匹配的正常妇女为对照组,向两组妇女发放《POF发病相关因素调查问卷》,分别采用单因素及Logistic多因素回归分析法分析影响POF的危险因素。结果 POF组绝经年龄、月经初潮时间、母乳喂养时间均早于对照组,差异有统计学意义(P<0.05);体重指数(BMI)、腰臀比均大于对照组,差异有统计学意义(P<0.05);抑制素B(INHB)水平低于对照组,差异有统计学意义(P<0.05);黄体生成素(LH)水平高于对照组,差异有统计学意义(P<0.05)。POF组不良情绪、接触毒物史、吸烟、酗酒、腮腺炎史、盆腔手术史、人流史、服用过促排卵药物史、家族史、无生育比例显著高于对照组,差异均有统计学意义(P<0.05)。Logistic多因素分析显示:INHB水平低下、不良情绪、接触毒物史、吸烟、腮腺炎史、盆腔手术史、家族史是青岛市女性发生POF的独立危险因素。结论养成良好生活方式,保持积极心态,避免接触有害环境能有效预防POF的发生,血清INHB、LH水平可作为POF早期预测指标。
Objective To investigate the occurrence and risk factors of premature ovarian failure (POF) in Qingdao women and provide guidance for clinical prevention and treatment of POF. Methods A total of 120 POF patients treated in Qingdao Third People’s Hospital from January to December in 2015 were enrolled as POF group. Another 120 normal women with normal menstruation and normal age were selected as control group, Two groups of women issued a “questionnaire related to the incidence of POF”, respectively, using single factor and Logistic regression analysis of risk factors for POF. Results The menopausal age, menarche time and breastfeeding time in POF group were significantly higher than those in control group (P <0.05). Body mass index (BMI) and waist-hip ratio were significantly higher than those in control group (P <0.05). The level of INHB was lower than the control group (P <0.05), and the level of LH was higher than that of the control group (P <0.05) . POF group had negative emotions, contact poison history, smoking, alcoholism, history of mumps, history of pelvic surgery, history of abortion, history of taking ovulation medicine, family history and no birth rate, the differences were statistically significant ( P <0.05). Logistic multivariate analysis showed that low INHB levels, adverse emotions, exposure to poison, smoking history, mumps history, pelvic surgery history and family history were independent risk factors for POF in Qingdao women. Conclusions To develop a good lifestyle, to maintain a positive attitude, to avoid contact with harmful environment can effectively prevent the occurrence of POF, serum INHB, LH levels can be used as POF early predictors.