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目的:研究CC亚族趋化因子单核细胞趋化蛋白-4(MCP-4/CCL13)在类风湿关节炎(RA)患者外周血的表达水平,并分析MCP-4的水平与疾病活动性的关系,以探讨MCP-4在RA发病机制中的作用。方法:应用酶联免疫吸附实验(ELISA)定量方法测定40例RA患者、20例其它自身免疫性疾病患者和20例正常健康对照者血清MCP-4水平。分析RA组血清MCP-4水平是否与ESR、CRP、RF及双手放射学检查等指标具有相关性。结果:RA组血清MCP-4水平为(203.79±18.64)pg/mL,其它自身免疫性疾病对照组血清MCP-4水平为(207.76±40.37)pg/mL,正常健康对照组血清MCP-4水平为(125.13±11.08)pg/mL。RA组、其它自身免疫性疾病对照组血清MCP-4水平与正常健康对照组相比均有统计学意义(P<0.05),RA组与其它自身免疫性疾病对照组间无统计学意义(P=0.787),RA活动期患者血清MCP-4水平(214.86±24.46)pg/mL和非活动期患者血清MCP-4水平(190.27±29.11)pg/mL比较无统计学意义(P=0.065)。RA组血清MCP-4水平与ESR、CRP、RF及双手X片分期无相关性。结论:RA组的血清MCP-4水平高于正常健康对照组,但与ESR、CRP、RF及双手X片分期无相关性。MCP-4可能参与了RA的发病过程。
Objective: To investigate the expression of chemokines chemokine MCP-4 / CCL13 in peripheral blood of patients with rheumatoid arthritis (RA) and to analyze the relationship between MCP-4 level and disease activity In order to explore the role of MCP-4 in the pathogenesis of RA. Methods: Serum levels of MCP-4 in 40 patients with RA, 20 patients with other autoimmune diseases and 20 normal controls were determined by enzyme-linked immunosorbent assay (ELISA). The level of serum MCP-4 in RA group was correlated with ESR, CRP, RF and two-handed radiological examination. Results: Serum levels of MCP-4 in RA group were (203.79 ± 18.64) pg / mL, serum MCP-4 level was (207.76 ± 40.37) pg / mL in other autoimmune diseases control group, (125.13 ± 11.08) pg / mL. The levels of serum MCP-4 in RA and other autoimmune diseases control groups were significantly higher than those in normal control group (P <0.05), and there was no significant difference between RA group and other autoimmune diseases control group (P = 0.787). Serum MCP-4 level (214.86 ± 24.46) pg / mL in active RA patients and serum MCP-4 levels in inactive patients (190.27 ± 29.11) pg / mL were not statistically significant (P = 0.065). The level of serum MCP-4 in RA group was not correlated with ESR, CRP, RF and stage X-ray. Conclusion: The level of serum MCP-4 in RA group is higher than that in normal healthy group, but it has no correlation with ESR, CRP, RF and stage X-ray. MCP-4 may be involved in the pathogenesis of RA.