眼表面的概念由Thoft和Friend于 1979年提出 ,眼表疾病的概念由Nelson于 1980年提出。在解剖学上 ,眼表是由上下睑缘皮肤为界的整个黏膜上皮衬里组成。在组织学上 ,这个上皮表面覆盖着两个主要领域 ,即角膜和结膜。近 2 0年来 ,有关眼表上皮以及眼表重建的研究已取得进展 ,眼表 The concept of ocular surface was proposed by Thoft and Friend in 1979, and the concept of ocular surface disease was proposed by Nelson in 1980. Anatomically, the ocular surface is composed of the entire mucosal epithelium lining the upper and lower eyelid skin. Histologically, this epithelial surface is covered in two main areas, the cornea and the conjunctiva. Nearly 20 years, the research on ocular surface epithelial and ocular surface reconstruction has made progress, ocular surface