多发性骨髓瘤(M、M)是浆细胞恶性增生性疾病。主要表现为骨髓浆细胞浸润、骨质破坏、血/尿中出现单克隆免疫球蛋白(M蛋白)。各种免疫球蛋白重链不同,而单个免疫球蛋白分子的两条轻链总是相同的。IgG型M、M中,K/λ约为2/1。我们发现一例单克隆IgG型M、M伴双轻链现象患者,现将其血、尿及骨髓免疫化学分析结果报告如下。一.病史摘要王××,女,38岁,已婚,汉族,四川籍。因全身多发性骨疼伴进行性乏力于1985年6月30日入院。患者于2~+年前无明显诱因出现双下肢骨骼疼痛,伴身软乏力。骨痛逐渐累及全身骨骼,乏力进行性如重,严重时步行困难。1~+年前日饮水量及夜尿量明显增加。并出现牙龈渗血。曾在外院按“风湿病”治疗 Multiple myeloma (M, M) is a plasma cell malignant proliferative disease. Mainly for bone marrow plasma cell infiltration, bone destruction, blood / urine monoclonal immunoglobulin (M protein). The various immunoglobulin heavy chains are different, whereas the two light chains of a single immunoglobulin molecule are always the same. IgG type M, M, K / λ is about 2/1. We found a monoclonal IgG M, M with double light chain phenomenon, now the blood, urine and bone marrow immunochemical analysis results are reported as follows. A history summary Wang × ×, female, 38 years old, married, Han nationality, Sichuan membership. Due to systemic multiple bone pain associated with progressive fatigue in June 30, 1985 admission. Patients with 2 ~ + years ago no obvious incentive to appear lower extremity bone pain, accompanied by soft fatigue. Bone pain gradually involving the whole body skeleton, weakness progressive as heavy, severe walking difficulties. 1 ~ + years ago, drinking water and urine output increased significantly. And gum bleeding. Once outside the hospital by “rheumatism” treatment