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药动学(pharmacokinetics,PK)研究药物在体内的吸收、分布、代谢与排泄,药效学(pharmacodynamics,PD)为药物剂量对药效的影响以及药物对临床疾病的效果。抗菌药物治疗传统上以体外药效学数据MIC,MBC,KCS,PAE等为指导,上述参数虽能在一定程度上反映抗菌药物的抗菌活性,但其测定方法是将细菌置于固定的抗菌药物浓度中测得的,而体内抗菌药物浓度是一个连续变化的状态,不能体现抗菌药物杀菌的动态过程,抗菌药物PK／PD研究将药物动力学与体外药效动力学参数综合,旨在研究某一给药剂量对应的时间一效应过程。现根据抗菌药物PK／PD参数,对各类抗菌药物给药方案的制订作一简要分析,以期优化临床给药方
Pharmacokinetics (PK) studies the absorption, distribution, metabolism and excretion of drugs in the body, pharmacodynamics (PD) as the effect of drug dosage on the drug efficacy and the effect of drugs on clinical diseases. Antibacterial therapy traditionally in vitro pharmacodynamic data MIC, MBC, KCS, PAE, etc. as a guide, although the above parameters can reflect the antibacterial activity of antibacterial drugs to some extent, but its determination method is to place the bacteria in a fixed antimicrobial drug Concentration in the measured, and in vivo antibacterial concentration is a continuous change in the state, can not reflect the dynamic process of antibacterial sterilization, antibacterial PK / PD pharmacokinetic pharmacokinetics and in vitro pharmacokinetic parameters to study a certain A dose of the corresponding time-effect process. Now based on the antimicrobial PK / PD parameters, the preparation of various types of antimicrobial drug programs for a brief analysis, with a view to optimizing the clinical prescription