本文综述应用促性腺激素释放激素(G-nRH)抗生育的方法并评价最有前途的避孕途径。GnRH可通过三个不同方式干扰生育:(1)在垂体门脉中GnRH抗体中和GnRH,阻止GnRH到达垂体的GnRH受体部位;(2)GnRH的化学拮抗物能阻断GnRH受体;(3)慢性给药时GnRH刺激物产生抑制作用。一、GnRH在男性中的抗生育作用(一)GnRH抗体:用GnRH合成多肽主动免疫大鼠和家兔,以产生抗体中和内源性GnRH。结果:垂体产生LH与FSH受到抑制;血中LH与FSH下降;睾丸的产生与 This article reviews the use of gonadotropin-releasing hormone (G-nRH) for antifertility and reviews the most promising contraceptive methods. GnRH interferes with fertility in three different ways: (1) GnRH antibodies neutralize GnRH in the pituitary portal to prevent GnRH from reaching the pituitary GnRH receptor site; (2) GnRH chemical antagonists block GnRH receptors; ( 3) Inhibition of GnRH stimulants during chronic administration. Anti-fertility effects of GnRH in men (a) GnRH antibody: Active immunization of rats and rabbits with GnRH synthetic peptides to generate antibodies to neutralize endogenous GnRH. Results: The LH and FSH produced by the pituitary were inhibited; LH and FSH in the blood were decreased;