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在神经递质和受体水平,癫癎的发病机制可累及抑制性的γ-氨基丁酸(GABA)递质受体系统和兴奋性的谷氨酸递质受体系统。谷氨酸受体又分为离子型和代谢型两种。目前的研究热点集中在代谢型谷氨酸受体(mGluRs)癫癎发病机制方面。本文将从 mGluRs 在癫癎动物模型包括转基因动物模型及临床研究方面简述 mGluRs 与癫癎的关系。代谢型谷氨酸受体家族谷氨酸是大脑中的主要兴奋性神经递质。以前认为突触释放谷氨酸仅作用于离子型受体而打开离子通道。自1985年起,开始认为谷氨酸也通过 G-
At neurotransmitter and receptor levels, the pathogenesis of epilepsy can involve both the inhibitory gamma-aminobutyric acid (GABA) receptor system and the excitatory glutamate receptor system. Glutamate receptors are divided into ionic and metabolic two. The current research focuses on the pathogenesis of epilepsy with metabotropic glutamate receptors (mGluRs). This article will briefly describe the relationship between mGluRs and epilepsy in mGluRs in animal models of epilepsy including transgenic animal models and in clinical studies. The metabotropic glutamate receptor family glutamate is the major excitatory neurotransmitter in the brain. It was previously thought that synaptic release of glutamate acts only on ionic receptors and opens up ion channels. Since 1985, it has been assumed that glutamate also passes through the G-