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鉴于SLE病人中抗SSA和(或)抗SSB抗体与疾病有某些关系,这两种抗体的出现能使光敏性皮肤病、类风湿因子阳性和干燥综合征的发生率增高。Provost等指出有抗胞浆抗体的SLE病人,光敏性皮损发生率高,这些抗体可能作为开始以皮损为主的SLE病人将来出现系统症状的标志。本文报告伴有干燥综合征和抗胞浆抗体的SLE病人的临床及血清学特征。从42例SLE病人中采取血清标本。用荧光抗体方法检测ANA,用琼脂凝胶双向扩散技术检测抗核及抗胞浆抗体。用已知抗RNP、抗SM、抗SSA和SSB的标准血清标本做为对照。并从皮损处取活检,做直接免疫荧光检查。
Given the relationship between anti-SSA and / or anti-SSB antibodies and disease in SLE patients, the presence of these two antibodies can lead to an increased incidence of photosensitive dermatitis, rheumatoid factor-positive and Sjogren’s syndrome. Provost et al. Pointed out that SLE patients with anti-cytoplasmic antibodies had a high incidence of photosensitive skin lesions and these antibodies may serve as a hallmark of future systemic symptoms in patients with SLE who are primarily skin lesions. This article reports the clinical and serological features of SLE patients with Sjogren’s syndrome and anti-cytoplasmic antibodies. Serum samples were taken from 42 SLE patients. ANA was detected by fluorescent antibody method and anti-nuclear and anti-cytoplasmic antibodies were detected by agar gel bi-directional diffusion technique. Standard anti-RNP, anti-SM, anti-SSA and SSB serum samples were used as controls. Take biopsy from the skin lesions, do direct immunofluorescence.