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脂联素是由脂肪组织分泌的一种细胞因子,与心血管疾病密切相关。脂联素通过抗炎和抗氧化抑制动脉粥样硬化发生。脂联素可促进血管生成,并具有保护心肌免受缺血再灌注损伤和减轻高压力负荷导致的心肌肥厚的功能。脂联素主要通过激活腺苷酸活化的蛋白激酶、环磷酸腺苷-蛋白激酶A等信号通路而发挥对心血管的保护作用。该文主要针对脂联素在心血管系统中的作用及其分子机制的研究进展作一综述。
Adiponectin is a cytokine secreted by adipose tissue and is closely related to cardiovascular diseases. Adiponectin inhibits atherosclerosis through its anti-inflammatory and anti-oxidant properties. Adiponectin promotes angiogenesis and has the function of protecting myocardium from ischemia-reperfusion injury and relieving cardiac hypertrophy caused by high stress. Adiponectin exerts its cardiovascular protective effect mainly through activation of adenylate-activated protein kinase and cyclic adenosine monophosphate-protein kinase A signaling pathway. This review focuses on the role of adiponectin in the cardiovascular system and its molecular mechanisms.