越来越多的证据表明,在正常动物和人体血清中存在着大量自身抗体.它们以低亲和力、多反应性(polyreactivity)为特点,被称为天然自身抗体,或NAA(naturalautoantibody),以区别于病理情况下出现的自身抗体.NAA的存在和被发现,向传统的“自身抗体有害”的观点提出了挑战,给当代免疫学提供了新的研究课题.关于NAA的发生机制和生理意义,目前尚无定论. There is growing evidence that a large number of autoantibodies exist in normal animal and human sera and are characterized by low affinity and polyreactivity called natural autoantibodies or NAA (naturalautoantibody) The autoantibodies that appear in the pathological situation.The existence and the discovery of NAA have posed challenges to the traditional viewpoint of “autoantibodies” and provided new research topics for contemporary immunology.As to the mechanism of occurrence and physiological significance of NAA, There is no conclusion yet.