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Experiments on aortic strips of rabbit andrat showed that tetrandrine exerted relaxationeffect on vascular smooth muscle,and itspotency was 3 times that of dihydralazine.Blocking the α-and β-receptors by phentola-mine and propranolol respectively did notaffect the relaxation produced by tetrandrine.The contraction response of calcium-deplet-ed aortic strips induced by KC1 was antagonizedby tetrandrine.When the intra-and extracel-lular calcium-dependent responses were isolatedby noradrenaline,these two types of responseswere both inhibited by tetrandrine,and the in-hibition of the intracellular calcium-dependentcontraction was prominant.Experimental results suggested that therelaxation effect of tetrandrine on vascularsmooth muscle was related to its anti-calciumaction.
Experiments on aortic strips of rabbit andrat showed that tetrandrine exerted relaxation effect on vascular smooth muscle, and its potency was 3 times that of dihydralazine. Blocking the alpha-and beta-receptors by phentola-mine and propranolol respectively did not affect the relaxation produced by tetrandrine. contraction response of calcium-deplet-ed aortic strips induced by KC1 was antagonizedby tetrandrine.When the intra-and extracel-lular calcium-dependent responses were isolated by noradrenaline, these two types of responses were all inhibited by tetrandrine, and the in-hibition of the intracellular calcium-dependentcontraction was prominant. Experimental results suggested that therelaxation effect of tetrandrine on vascularsmooth muscle was related to its anti-calciumaction.