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将卡介菌多糖核酸（ＢＣＧ＿ＰＳＮ）及肿瘤坏死因子（ＴＮＦ＿α）用于荷肉瘤（Ｓ１８０）小鼠的治疗。结果证明，ＢＣＧ＿ＰＳＮ（０５ｍｇ／ｍｌ）及ＴＮＦ＿α（１０００Ｕ／ｍｌ）均能显著抑制Ｓ１８０实体瘤的生长，抑瘤率分别为５８１０％和３６２５％，抑瘤率与荷瘤鼠脾细胞的ＩＬ＿２诱生水平呈正的直线相关。ＢＣＧ＿ＰＳＮ还能显著延长荷Ｓ１８０腹水瘤鼠的存活期，生命延长率达３１５％。ＴＮＦ可能由于它的毒副作用而使其抑瘤效果低于ＢＣＧ＿ＰＳＮ，且与后者无协同作用。
The BCG-PSG and tumor necrosis factor (TNF-α) were used in the treatment of Schistosomiasis (S180) mice. The results showed that BCG_PSN (0.5 mg/ml) and TNF_α (1000 U/ml) significantly inhibited the growth of S180 solid tumors, and the tumor inhibition rates were 58. 10% and 36. 25%, respectively. The level of IL 2 induced by spleen cells was positively linear. BCG_PSN can also significantly prolong the survival of S180 ascites tumor mice, with a life extension rate of 31.5%. TNF may have lower anti-tumor effect than BCG_PSN due to its toxic side effects, and it has no synergistic effect with the latter.