Preparation and spectroscopic properties of 2',5'-dideoxynucleosidylcobalamins

来源 :Chinese Journal of Chemistry | 被引量 : 0次 | 上传用户:wokaoyan123
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Two new coenzyme B12 analogues, 2’,5’-dideoxycytidylcobalamin (2a) and 2’,5’-dide-oxyuridinylcobalamin (2b), and two others, 2’,5’-dideoxyadenosylcobalamin (2c), and 5’-deoxy-thymidylcobalamin (2d) were prepared by an improved method. All the four analogues were investigated by UV-vis and 2D 1H NMR spectroscopy. The comparisons and discussion about their spectroscopic properties were done. Two new coenzyme B12 analogues, 2 ’, 5’-dideoxycytidylcobalamin (2a) and 2’, 5’-dide- oxyuridinylcobalamin (2b), and two others, 2 ’, 5’-dideoxyadenosylcobalamin All the four analogues were investigated by UV-vis and 2D 1H NMR spectroscopy. The comparisons and discussion about their spectroscopic properties were done.
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