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雌激素受体α(ERα)在乳腺癌发生发展中起重要作用 ,其活性受共调节因子的调节。对ERα共调节因子的种类、作用方式、在乳腺癌细胞中的变化及其在mRNA选择性剪接中的作用分别作了概述。
Estrogen receptor alpha (ERa) plays an important role in the development of breast cancer and its activity is regulated by co-regulatory factors. The types of ERα co-regulatory factors, the mode of action, the changes in breast cancer cells and their roles in alternative mRNA splicing are summarized respectively.