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基于短暂性脑缺血发作的中医、西医临床病症特点,对目前现有的短暂性脑缺血发作模型进行总结归纳,通过整理分析短暂性脑缺血发作各个动物模型的优缺点、中西医诊断标准以及临床症状吻合度,进一步提出相应动物模型的评价思路及改进方法。而且还发现短暂性脑缺血发作动物模型虽然造模方法比较多,但不能很好地反映该病的短暂性、可逆性、反复发作性等典型特征,与临床病症特点差异较大,且缺少对该动物模型造模成功与否的合理的量化标准。通过利用现有的单因素动物模型相结合,建立与临床病症相结合的、更接近人类短暂性脑缺血发作典型症状的复合动物模型,复制出能更加吻合临床病症特点的动物模型。建立合理的模型量化标准,体现其中西医病因,完善一套系统完整的模型评价方法,是短暂性脑缺血发作动物模型未来的发展方向。
Based on the characteristics of clinical symptoms of traditional Chinese medicine and western medicine based on transient ischemic attack, the current transient ischemic attack model is summarized. By analyzing and analyzing the advantages and disadvantages of various animal models of transient ischemic attack, Standard and clinical symptoms of the fit, and further proposed the evaluation of the corresponding animal models and ways to improve. But also found that although the animal model of transient ischemic attack more modeling methods, but it can not well reflect the transient nature of the disease, reversible, recurrent and other typical features, and characteristics of clinical symptoms vary greatly, and the lack of The animal model modeling success or not reasonable quantitative criteria. By using the existing single-factor animal model, a composite animal model that is closer to the typical symptoms of human transient ischemic attack combined with clinical conditions is established and an animal model that more closely matches the clinical symptoms is duplicated. To establish a reasonable model of quantitative criteria, reflecting the cause of Western medicine, improve a set of systematic and complete model evaluation method, is the future development of transient ischemic attack animal model.