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本文介绍单核吞噬细胞尤其是肺臣噬细胞的生物学作用、正常条件下来源和动力学概况,以及炎症期间单核细胞生成的体液性调节。[单核吞噬细胞的特性] 单核吞噬细胞系包括体内各部位的巨噬细胞、循环的单核细胞和骨髓中的前单核细胞与成单核细胞。后二者较前二者幼稚。单克隆扰体特异结合表明了这些细胞的异质性,如腹腔巨噬细胞与肺巨噬细胞所结合的单克隆抗体是不同的。但对局部环境如肺巨噬细胞摄取表面活性物质,在这些差异发生上的作用程度是不清楚的。[单核吞噬细胞的内摄作用] 单核吞噬细胞表面有C_(3b)受体和IgG的FC段(Fcr)受体。Fcr受体介导被调
This article describes the biological role of mononuclear phagocytes, especially pulmonary alveolar macrophages, their source and kinetic profiles under normal conditions, and the humoral regulation of monocyte production during inflammation. [Characteristics of Mononuclear Phagocytes] Mononuclear phagocyte cells include macrophages in various parts of the body, circulating monocytes, and pre-monocytes and monocytes in the bone marrow. The latter two are naive. The specific binding of monoclonal clones shows the heterogeneity of these cells, such as peritoneal macrophages and lung macrophages are bound by monoclonal antibodies are different. However, the extent of the effect on these differences in the uptake of surface-active substances in the local environment, such as lung macrophages, is unclear. [Endocytosis of Mononuclear Phagocytes] Mononuclear phagocytes have Fc receptor (Fc) receptors on the surface of C_ (3b) receptors and IgG. Fc receptor mediated mediation