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1954年,Vigneaud等在世界上首次确定了催产素的化学结构,这一成果被视为肽类激素研究的重大突破,30余年来,对催产素的研究日臻广泛和深入,各种催产素制剂已广泛应用于临床。催产素受体的发现使进一步揭示催产素的作用原理成为可能。迄今研究表明,子宫平滑肌细胞催产素受体在人类分娩发动中可能起着很重要的作用。本文复习部分文献,作一综述。一、催产素受体的特征及影响因素催产素为9肽激素,主要由下丘脑视上核及室旁核神经元合成,经位于垂体后叶的神经终末释放,进入血循环,作用于靶细胞。一般认为肽类激素的受体属膜受体,即受体位于靶细胞膜表面。已经证明,人和动物的子宫平滑肌细胞催产素受体位于细胞膜。催产素首先和靶细胞膜受体结合,再
In 1954, Vigneaud et al. Determined the chemical structure of oxytocin for the first time in the world. This result is regarded as a major breakthrough in the research of peptide hormones. For more than 30 years, the research on oxytocin has been extensive and in-depth. Various oxytocin preparations Has been widely used in clinical. The discovery of oxytocin receptors makes it possible to further reveal the role of oxytocin. So far, studies have shown that uterine smooth muscle cell oxytocin receptors may play a very important role in the initiation of human delivery. This article reviews some of the literature for a review. First, the characteristics of oxytocin receptors and factors oxytocin 9-peptide hormone, mainly by the hypothalamic supraoptic nucleus and paraventricular nucleus neurons synthesis, release through the terminal pituitary in the nerve terminal, into the blood circulation, the role of the target cell. It is generally believed that the receptor of peptide hormones belongs to the membrane receptor, that is, the receptor is located on the surface of the target cell membrane. It has been shown that human and animal uterine smooth muscle cell oxytocin receptors are located in the cell membrane. Oxytocin binds to the target cell membrane receptor first and then