病人摄入偶氮染料后引起超敏反应而致复发性过敏性紫癜的报道罕见。酒石黄(Tartrazlne)为一食物、药物和化妆品条例所批准的食品添加剂,存在于多种饮料、食品、化妆品及药品(包括Atafax)中。本文作者描述一患者用酒石黄激发试验后出现复发性紫癜反应。患者为—51岁男性,有长期患寒冷性荨麻疹史,1982年由于腹痛而诊断为憩室炎。患者发现由于摄食鸡蛋和奶酪,四肢及下腹部反复发生无症状性紫癜9个月。检查发现上述部位有小而不可触知的瘀点。实验室检查显示血凝无异常,SGPT、甘油三酯和尿酸中度增高,类风湿因子1:20阳性,但冷球蛋白和冷纤维蛋白阴性。免疫球蛋白包括IgE均正常。循环免疫复合物缺乏,但发现CH_(50)低下。紫癜活检示在真皮上部小血管周围有少量淋巴细胞浸润、免疫荧光显示在血管壁有IgA、IgM和C_3沉积,真皮表皮交界处有IgM的粒状沉积,真皮有IgM荧光体沉积。常规寻找抗原未获成功。即使发现有抗HBs和抗HBe抗体,患者的ANA、TASL、弓形体病染料试验和HBsAg仍阴 Azoospermia patients after the introduction of hypersensitivity caused by recurrent allergic purpura rarely reported. Tartrazine is a food additive approved by the Food, Drug, and Cosmetic Regulations and is found in a variety of beverages, foods, cosmetics and pharmaceuticals, including Atafax. The authors describe a recurrent purpuric reaction in a patient who has been challenged with tartrazine. The patient, a -51-year-old man, had a long history of cold-headed urticaria and was diagnosed with diverticulitis in 1982 due to abdominal pain. Patients were found to have recurrent asymptomatic purpura in their extremities and lower abdomen for 9 months due to their eggs and cheese. Check found that these parts have a small but not palpable petechia. Laboratory tests showed no abnormalities in blood clotting, moderate increases in SGPT, triglycerides, and uric acid, with a 1:20 rheumatoid factor but cryoglobulin and cold fibrin negative. Immunoglobulins, including IgE, are normal. Circulatory immune complexes are deficient, but CH_ (50) is found to be low. Purpura biopsy showed a small amount of lymphocyte infiltration around the small blood vessels in the upper dermis. Immunofluorescence showed IgA, IgM and C_3 deposition on the vascular wall, granular deposition of IgM on the dermis epidermis and deposition of IgM on the dermis. The routine search for antigens failed. Even if anti-HBs and anti-HBe antibodies were found, the patient’s ANA, TASL, toxoplasmosis dye test and HBsAg-negative