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为探讨抑凋亡基因Ｂｃｌ－２与子宫内膜癌发生发展及预后的关系，用ＡＢＣ免疫组化法对４０例正常子宫内膜和６０例子宫内膜癌Ｂｃｌ－２蛋白表达状况进行检测。结果发现Ｂｃｌ－２表达在正常子宫内膜中呈周期性变化，其表达由增生早期开始逐渐增强，到增生晚期表达最强，进入分泌期则减弱乃至消失。子宫内膜癌中Ｂｃｌ－２表达水平远远低于增生期内膜Ｂｃｌ－２表达水平，且表达于预后较好的腺棘癌、乳头状腺癌、单纯腺癌组织，而浆液性腺癌和鳞癌组织中则无表达；分化程度低、期别晚者，Ｂｃｌ－２表达弱（Ｐ＜０．０１）；在５例伴有内膜增生过长的内膜癌中，增生过长内膜的表达明显强于癌组织和增生期内膜的表达。由此推测Ｂｃｌ－２高表达可能在子宫内膜增生过长的发生中起着重要作用，而内膜癌中Ｂｃｌ－２表达明显减弱，其作用仍待深入研究。Ｂｃｌ－２的高表达可提示预后较好，但尚需进一步随访证实
To investigate the relationship between the expression of Bcl-2 and the occurrence, development and prognosis of endometrial carcinoma, the expression of Bcl-2 protein in 40 cases of normal endometrium and 60 cases of endometrial carcinoma was detected by ABC immunohistochemistry. The results showed that the expression of Bcl-2 changed periodically in normal endometrium. The expression of Bcl-2 gradually increased from the early stage of hyperplasia to the late stage of hyperplasia, and then decreased or even disappeared during the secretory phase. The expression of Bcl-2 in endometrial carcinoma is much lower than that in proliferative endometrium, and it is expressed in adenocarcinoma, papillary adenocarcinoma and adenocarcinoma with good prognosis, while serous adenocarcinoma and There was no expression in squamous cell carcinoma; the expression of Bcl-2 was low in poorly differentiated and late-stage patients (P <0.01); in 5 cases of endometrial hyperplasia with endometrial hyperplasia Membrane expression was significantly stronger than that in the cancerous tissue and in proliferating endometrium. It is speculated that the high expression of Bcl-2 may play an important role in the occurrence of endometrial hyperplasia, while the endometrial carcinoma Bcl-2 expression was significantly weaker, its role remains to be further studied. High expression of Bcl-2 may suggest a good prognosis, but still need further follow-up confirmed