Wernicke脑病（WE）于1881年Wernicke首先描述，在我国罕有报道。本病的基本病理特征为第三、四脑室旁、导水管周围灰质、乳头体部的毛细血管增生、点状出血、星形细胞胶质增生，其发病机理与维生素B1缺乏有关。部分WE患者以大剂量维生素B1治疗可获较好予后，但常因诊断不及时? Wernicke encephalopathy (WE) was first described by Wernicke in 1881 and rarely reported in our country. The basic pathological features of the disease for the third and fourth ventricle next to the aqueduct around the gray matter, papillary body capillaries hyperplasia, punctate bleeding, astrocyte glial hyperplasia, the pathogenesis of vitamin B1 deficiency. Some WE patients with high doses of vitamin B1 treatment may be better to give, but often due to diagnosis is not timely?