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目的:探讨早期胃癌(early gastric cancer,EGC)T1a患者发生淋巴结转移的危险因素。方法:回顾性分析行手术治疗的466例早期胃癌T1a患者的临床病理资料,通过卡方检验、Fisher确切概率法及Logistic回归模型分析,研究早期胃癌T1a淋巴结转移与各临床病理因素之间的关系。结果:单因素分析显示,年龄、性别、肿瘤部位及组织学类型与早期胃癌T1a淋巴结转移具有相关性(P<0.05)。多因素分析表明,患者年龄(P=0.029)、性别(P=0.020)和组织学类型(P=0.045)是早期胃癌T1a发生淋巴结转移的独立危险因素。分层分析示,年龄<65岁、肿瘤分化程度低的女性患者更容易发生淋巴结转移,而年龄≥65岁的患者发生淋巴结转移的概率较低。结论:患者的年龄、性别以及肿瘤的组织学类型是影响早期胃癌T1a发生淋巴结转移的独立危险因素。
Objective: To investigate the risk factors of lymph node metastasis in patients with early gastric cancer (EGC) T1a. Methods: The clinicopathological data of 466 patients with T1a gastric cancer were retrospectively analyzed. The relationship between T1a lymph node metastasis and clinicopathological factors was analyzed by Chi-square test, Fisher’s exact test and logistic regression analysis . Results: Univariate analysis showed that age, gender, tumor location and histological type had correlation with T1a lymph node metastasis in early gastric cancer (P <0.05). Multivariate analysis showed that patient age (P = 0.029), gender (P = 0.020) and histological type (P = 0.045) were independent risk factors for lymph node metastasis in early gastric cancer T1a. Stratified analysis showed that women younger than 65 years old with low degree of tumor differentiation were more likely to have lymph node metastases, while patients with age ≥65 years had a lower probability of lymph node metastasis. Conclusion: The age, sex and the histological type of the tumor are independent risk factors for lymph node metastasis in early gastric cancer T1a.