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目的观察中药辅助化疗治疗耐多药肺结核病的临床疗效。方法将64例耐多药肺结核病患者随机分为治疗组36例及对照组28例。2组均予正规抗结核药物,治疗组加服自制的养阴敛肺益气方,疗程为6个月。治疗期间观察2组患者临床症状体征改善情况;观察外周血细胞亚群、各细胞因子的水平变化及药物不良反应改善情况。结果治疗组各临床症状体征改善方面明显优与对照组(P<0.05);2组患者血T淋巴细胞亚群CD3、CD4、CD4/CD8水平较治疗前均有上升,CD8水平较治疗前均有下降,且治疗组上升、下降幅度明显优于对照组(P<0.05);2组患者细胞因子IL-12、IFN-γ水平较治疗前均有上升,SIL-2R水平较治疗前有下降,且治疗组上升、下降幅度明显优于对照组(P<0.05)。治疗组出现的不良反应明显低于对照组(P<0.05)。结论中药辅助化疗治疗耐多药肺结核病的临床疗效显著。
Objective To observe the clinical efficacy of traditional Chinese medicine adjuvant chemotherapy in the treatment of multidrug-resistant pulmonary tuberculosis. Methods Sixty-four MDR-TB patients were randomly divided into treatment group (36 cases) and control group (28 cases). The two groups were given regular anti-TB drugs, and the treatment group plus self-made Yangyin Conger Lifeng Yiqi prescription for 6 months. The clinical symptoms and signs of two groups were observed during treatment. The changes of peripheral blood cell subsets and cytokines and the improvement of adverse drug reactions were observed. Results The improvement of clinical symptoms and signs in the treatment group was significantly better than that in the control group (P <0.05). The levels of CD3, CD4 and CD4 / CD8 of blood T lymphocyte subsets increased in both groups compared with those before treatment (P <0.05). The levels of IL-12 and IFN-γ in the two groups increased compared with those before treatment, and the levels of SIL-2R in the two groups were significantly lower than those before treatment , And the treatment group increased and decreased significantly better than the control group (P <0.05). Adverse reactions in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion Chinese medicine adjuvant chemotherapy in the treatment of multidrug-resistant pulmonary tuberculosis clinical efficacy significantly.