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目的探讨血清学检查结合B超在胎儿非整倍体产前筛查中的应用价值。方法对来我院检查的3248位孕妇使用孕中期血清学三联(AFP、Freeβ-HCG、uE_3)检测联合B超检查进行胎儿非整倍体染色体病产前筛查,然后对筛查高风险孕妇进一步分析其羊水细胞染色体核型。结果共筛查出高危孕妇192例,其中血清学筛查高危孕妇183例,而超声检查胎儿异常9例,后进行羊水穿刺确诊唐氏综合征5例、18-三体综合征2例。结论联合使用血清学检测和超声检查的产前筛查方案,有利于提高胎儿非整倍体染色体异常的检出率,相对简单有效而无创,值得在临床推广使用。
Objective To investigate the value of serological test combined with B-ultrasound in antenatal screening of fetal aneuploidy. Methods A total of 3248 pregnant women who came to our hospital for prenatal screening for aneuploidy of chromosome were detected by the second trimester pregnancy test (AFP, Freeβ-HCG, uE_3) combined with B-ultrasound. Further analysis of amniotic fluid cell chromosome karyotype. Results A total of 192 high-risk pregnant women were screened out, of whom 183 were high-risk pregnant women serologically tested, 9 were abnormally diagnosed by ultrasound, 5 were confirmed Down’s syndrome by amniocentesis and 2 were trisomy 18. Conclusion Prenatal screening combined with serological test and ultrasonography is helpful to improve the detection rate of chromosomal abnormalities in fetal aneuploidy. It is relatively simple and effective and noninvasive, which is worth popularizing in clinic.