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目的探讨来非司酮对人中期妊娠胎盘功能的影响。方法对在该院中期妊娠计划引产１６～１９孕周的孕妇 １３例，在服用 １５０ ｍｇ米非司酮前和后 ２４ ｈ各采集肘静脉血 ５ ｍｌ，用放射免疫法检测血清雌激素（Ｅ_２）、孕激素（Ｐ）、绒毛膜促性腺激素（β－ＨＣＧ）及胎盘催乳素（ｈＰＬ）水平。结果服用米非司酮后孕妇血清Ｐ及β－ＨＣＧ显著下降（Ｐ＜０．０１，Ｐ＜０．０５），ｈＰＬ有下降趋势（Ｐ＞０．０５），Ｅ_２无显著性变化（Ｐ＞０．０５）。结论中孕妇女在使用来非司酮后胎盘分泌激素的功能受到影响。
Objective To investigate the effect of nifepristone on placental function in human metaphase. Methods Thirteen pregnant women scheduled for labor during the first 16 to 19 weeks of gestation were enrolled in this study. 5 ml of elbow venous blood was collected before and 24 hours after taking 150 mg mifepristone, and serum estradiol levels were measured by radioimmunoassay ), Progesterone (P), chorionic gonadotropin (β-HCG) and placental lactogen (hPL). Results The levels of serum P and β-HCG in pregnant women were significantly decreased after taking mifepristone (P <0.01, P <0.05), hPL had a decreasing trend (P> 0.05), and E 2 had no significant change (P> 0.05). Conclusions The function of placental secretion of hormones in middle-pregnant women is affected by the use of nifepristone.