37例重症肌无力病人,病程3～23年(平均5.5年)。病人按Osserman’s分级属Ⅱ级或病情更重。有35例做了胸腺切除术,大多数用强的松和抗胆碱酯酶药物治疗无效。 27例病人口服环磷酰胺每日1～2mg/kg,10例病人口服硫唑嘌呤每日1～2mg/kg,治疗时间3～51个月。结果是37例病人中30例(81%)对治疗有反应,其中4例缓解 37 patients with myasthenia gravis, duration of 3 to 23 years (mean 5.5 years). Osserman’s patients were classified as grade II or worse. Thirty-five had thymectomy, and most of the treatments with prednisone and anticholinesterase were ineffective. 27 patients received oral cyclophosphamide daily 1 ~ 2mg / kg, 10 patients azathioprine oral daily 1 ~ 2mg / kg, the treatment time of 3 to 51 months. As a result, 30 (81%) of the 37 patients responded to treatment, with 4 of them relieved