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成年 SD 大鼠饲喂高脂饲料两个月,造成高胆固醇血症后,随机分成4组.即 VC 组[1000 mg/(kg.d)],VE 组[100 mg/(kg.d)],VC 和 VE 组[VC 1000mg/(kg.d)和 VE 100 mg/(kg.d)]以及对照组.实验开始后改为基础饲料,自由饮水.实验前和实验中4周,6周和12周取血测血清总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C).结果证明:1)食物性高胆固醇血症的大鼠当摄入的脂肪和胆固醇一旦减低之后,外源性胆固醇骤减,大鼠具有迅速转化血液胆固醇的代谢功能,使过高的血清总胆固醇水平下降至正常;2)大剂量 VC 和(或)VE 用于食物性高胆固醇血症时,如与撤除高脂高胆固醇食物同时使用,其治疗效果不明显.
Adult SD rats were fed high-fat diet for two months, resulting in hypercholesterolemia. They were randomly divided into four groups: VC group [1000 mg/(kg.d)] and VE group [100 mg/(kg.d) ], VC and VE groups [VC 1000mg/(kg.d) and VE 100 mg/(kg.d)] and the control group. After the experiment was started, the basal diet was changed, free drinking water. Before and during the experiment, 4 weeks, 6 Blood samples were taken at week 12 and week 12 to measure serum total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C). The results showed that: 1) When dietary hypercholesterolemia was reduced in fat and cholesterol intake, Exogenous cholesterol abruptly decreases, rats have the metabolic function of rapidly transforming blood cholesterol, which makes excessive serum total cholesterol levels drop to normal; 2) when large doses of VC and/or VE are used for food-induced hypercholesterolemia, If used with the removal of high fat and high cholesterol foods, the therapeutic effect is not obvious.