毛细胞白血病 ( HCL)是一种少见类型的白血病 ,发病率约占白血病的 2 % ,而儿童患者更少 ,临床统计发病年龄平均为 5 0岁。自 1 95 8年 Bouroncle等 [1]首先用透射电镜观察该病的血细胞后 ,电镜观察已成为研究和诊断该病的重要手段。毛细胞在透射电镜下以胞浆呈现许多不规则突 Hairy cell leukemia (HCL) is a rare type of leukemia with a prevalence of about 2% of leukemias and fewer children, with an average clinical age of onset of 50 years. Since Bouroncle et al. [1] first observed the blood cells of the disease by transmission electron microscopy in 1958, electron microscopy has become an important method to study and diagnose the disease. Hair cells in the cytoplasm under transmission electron microscopy showed many irregular processes