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目的探讨糖化血红蛋白(HbA1c)及糖化血清蛋白(GSP)在妊娠糖尿病诊断的临床应用价值。方法选取280例孕妇为研究对象,按临床诊断分为妊娠糖尿病组(GDM组)96例、糖耐量受损组(IGT组)85例及正常妊娠对照组99例,比较三组糖筛查、HbA1c、GSP水平及GDM组、IGT组中HbA1c、GSP的异常率,分析HbA1c、GSP在GDM诊断的方法学指标评价。结果三组分别糖筛查HbA1c、GSP血清水平差异均有统计学意义(P<0.05),组间两两比较差异均有统计学意义(P<0.05);IGT组、GDM组的组间、组内HbA1c、GSP的异常率差异有统计学意义(P<0.05),GSP有较高的灵敏度,HbA1c有较高的特异度及阳性预测值。结论 HbA1c、GSP在GDM的诊断中有一定应用价值。
Objective To investigate the clinical value of glycosylated hemoglobin (HbA1c) and glycosylated serum protein (GSP) in the diagnosis of gestational diabetes mellitus. Methods Two hundred and seventy pregnant women were selected as the study subjects. According to the clinical diagnosis, they were divided into 96 cases of GDM group, 85 cases of impaired glucose tolerance group (IGT group) and 99 cases of normal pregnancy control group. HbA1c, GSP levels and the abnormal rates of HbA1c and GSP in GDM group and IGT group. The methodological indexes of HbA1c and GSP in GDM were analyzed. Results There were significant differences in serum levels of HbA1c and GSP between the three groups (P <0.05), the differences between the two groups were statistically significant (P <0.05), IGT group, GDM group, There were significant differences in the abnormal rates of HbA1c and GSP among the groups (P <0.05). GSP had higher sensitivity and HbA1c had higher specificity and positive predictive value. Conclusion HbA1c and GSP have some value in the diagnosis of GDM.