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目的观察纳洛酮联合醒脑静注射液对重型颅脑外伤的临床疗效。方法将137例重型颅脑外伤的患者随机分为三组,联合组(纳洛酮联合醒脑静)49例,单用纳洛酮组46例,单用醒脑静组42例,用药10 d为1个疗程。对三组患者治疗后的意识状态好转的起效时间及10、20 d后神经功能评定、临床疗效的总有效率进行比较。结果联合组意识状态好转的起效时间、神经功能评定,临床疗效的总有效率均优于纳洛酮组及醒脑静组(P<0.05或P<0.01)。结论纳洛酮联合醒脑静注射液治疗重型颅脑外伤比单用纳洛酮或醒脑静注射液效果好,无明显不良反应。
Objective To observe the clinical effect of naloxone combined with xingnaojing injection on severe traumatic brain injury. Methods 137 patients with severe craniocerebral trauma were randomly divided into three groups: 49 cases in combination group (naloxone combined with xingnaojing), 46 cases in naloxone alone group, 42 cases in xingnaojing group alone and 10 cases in medication group d for a course of treatment. The onset time of improvement of consciousness state and the neurological function assessment and the total effective rate of clinical efficacy after 10 and 20 days of treatment were compared among the three groups. Results The onset time, neurological function evaluation and clinical curative effect in combination group were better than naloxone group and Xingnaojing group (P <0.05 or P <0.01). Conclusion Naloxone combined with xingnaojing injection in treating severe craniocerebral trauma is better than naloxone alone or xingnaojing injection, with no obvious adverse reactions.