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研究广西肝癌（ＨＣＣ）高发区居民饮用塘水致大鼠ＨＣＣ作用。实验采用黄曲霉毒素Ｂ１（ＡＦＢ１）致大鼠肝癌模型，Ｗｉｓｔａｒ大鼠１６０只，随机分为４组：Ａ组为空白对照组；Ｂ组注射ＡＦＢ１；Ｃ组饲０．２％塘水浓缩物；Ｄ组注射ＡＦＢ１和饲０．２％塘水浓缩物，检测γ－谷氨酰转肽酶阳性肝细胞增灶（ＧＧＴ阳性灶）和ＨＣＣ发生情况。ＧＧＴ阳性灶用电脑图像分析系统统计平面及立体指标。结果：Ｄ组ＧＧＴ阳性灶发生最多，ＨＣＣ发生率最高（４２．１％）；Ｃ组ＧＧＴ阳性灶比空白组多且大（Ｐ＜０．０５），但远少于Ｂ组（Ｐ＜０．０１）；Ｂ组ＨＣＣ发生率为２３．８％，Ａ、Ｃ两组无ＨＣＣ发生。提示：广西肝癌高发区饮用塘水中存在与ＨＣＣ发生相关的致癌或促癌物质，其作用弱于ＡＦＢ１，暴露于ＡＦＢ１同时饮用塘水可能增加罹患ＨＣＣ危险性。
To study the effects of drinking water from rats drinking pond water in Guangxi high incidence areas of liver cancer (HCC). Aflatoxin B1 (AFB1)-induced liver cancer model was used in the experiment. Wistar rats were divided into four groups randomly: A group was a blank control group; B group was injected with AFB1; C group was fed a 0.2% pond water concentrate. In group D, AFB1 and 0.2% pond water concentrates were injected to detect gamma-glutamyl transpeptidase-positive liver cells (GGT-positive foci) and the occurrence of HCC. The GGT-positive stove uses a computer image analysis system to calculate plane and stereo indicators. RESULTS: The majority of GGT-positive foci occurred in group D, with the highest incidence of HCC (42.1%). The number of GGT-positive foci in group C was greater than that in the control group (P<0.05), but far less than that of group B (P<0). .01); The incidence of HCC in group B was 23.8%. No HCC occurred in group A and C. Note: There are carcinogenic or cancer-promoting substances related to the occurrence of HCC in the drinking water of high incidence areas of Guangxi liver cancer, which is weaker than AFB1. Exposure to AFB1 and drinking water at the same time may increase the risk of HCC.