论文部分内容阅读
目的:探讨龙血竭对撕脱皮瓣微循环血流量及存活面积的影响。方法:75只SD大鼠随机分为基质组(A)、地塞米松组(B)、龙血竭组(C)。在大鼠背部制作一个蒂在尾部的3 cm×9 cm大小的撕脱伤皮瓣,皮瓣碾压撕脱后原位缝合。激光多普勒血流检测仪检测皮瓣微循环血流量,HE染色光镜观察皮瓣组织学改变,术后7,14 d计算皮瓣成活率。结果:C组近、中段血流与A、B组比较明显升高,具有统计学意义(P<0.05),术后7,14 d皮瓣成活率龙血竭组明显高于基质组和地塞米松组(P<0.01)。结论:龙血竭可提高撕脱皮瓣微循环血流量,从而提高皮瓣的成活面积。
Objective: To explore the effect of dragon’s blood on microcirculation blood flow and survival area of avulsed flap. Methods: Seventy-five SD rats were randomly divided into three groups: control group (A), dexamethasone group (B) and dragon’s blood group (C). A 3 cm × 9 cm avulsion flap pedicled on the tail was made on the back of the rat. The flaps were stamped and avulsed and then sutured in situ. Laser Doppler flowmetry was used to detect microcirculation flow of skin flaps. Histopathological changes of the flaps were observed with HE staining. The survival rate of the flaps was calculated at 7 and 14 days after operation. Results: The blood flow in group C was significantly higher than that in group A and B (P <0.05), and the survival rate of skin flap at 7 and 14 days after operation was significantly higher in dragon blood group than that in control group Dexamethasone group (P <0.01). Conclusion: DRG can improve microcirculation blood flow of avulsed flap and improve the survival area of flap.