论文部分内容阅读
给围产期昆明鼠喂服０．６及０，３ｍｇ·ｋｇ~（－１）／ｄ的雷藤氯内酯醇（Ｔ４），可导致部分母鼠产后泌乳减少，仔鼠缺奶死亡；引起母鼠肝脏线粒体损伤，琥珀酸脱氢酶（ＳＤＨ）活性分布改变，糖原合成减少，肝细胞空泡变性；肾脏小管细胞空泡变性；但不引起心脏、脾脏的病理改变。另于雌鼠怀孕第５天喂服Ｔ_４，于孕第１７天取材，用药组吸收胎及死胎未见高于对照组，亦未发现明显的宫内发育畸形。本实验说明Ｔ_４确是一种对胚胎毒性小的药物。
The perinatal period of Kunming mice fed with 0.6 and 0,3 mg·kg -1 /d of Letovanthrolactone (T4) resulted in the decrease of postpartum lactation and death of neonates. Causes mitochondrial damage in the liver of mice, changes in the distribution of succinate dehydrogenase (SDH) activity, reduced glycogen synthesis, vacuolar degeneration of hepatocytes, and vacuolar degeneration of renal tubular cells; but does not cause pathological changes in the heart and spleen. In addition, females were fed T_4 on the fifth day of pregnancy, and they were taken on the 17th day of pregnancy. Absorption of fetuses and stillbirths in the medication group was not found to be higher than in the control group, and no significant intrauterine growth abnormalities were found. This experiment shows that T_4 is indeed a drug that is less toxic to embryos.