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从原发性乳腺癌妇女的表现看,90％—95％通过常规检查未发现转移迹象,但是在5年内有半数病人复发。如果能对这些病人预测,就能制定出治疗方案,至少可使复发推迟。伦敦路德维格癌症研究所的W Howard Redding等发现,在复发的妇女中,57％为骨转移,从而提出以下可能性:在早期骨髓内已有转移的乳癌细胞,但这种早期表现尚不能用现在的诊断技术检出。他们从110名妇女多个部位采取骨髓标本,用乳腺细胞表面抗原(上皮膜抗原,EMA)的抗体探针对采取的骨髓细胞进行染色研究。通过常规染色技术在骨髓标本中未检出转移
From the performance of women with primary breast cancer, 90% - 95% found no evidence of metastasis through routine examination, but half of patients relapse within 5 years. If these patients can be predicted, treatment plans can be developed to at least delay recurrence. According to W Howard Redding of Ludwig Cancer Institute in London, 57% of relapsed women have bone metastases, which raises the possibility that metastatic breast cancer cells may have been present in early bone marrow, but this early manifestation Cannot be detected using current diagnostic techniques. They used bone marrow samples from multiple sites in 110 women and used bone marrow cells stained with antibody probes for mammary cell surface antigens (epithelial membrane antigen, EMA). No detection of metastases in bone marrow specimens by conventional staining techniques