基质金属蛋白酶(matrix metalloproteinases.MMPs)是一组结构与功能同源的锌离子依赖性蛋白酶超基因家族,能特异性地降解细胞外基质(extra cellular matrix,ECM),并可以被基质金属蛋白酶组织抑制剂(tissue inhibitors of metalloproteinases,TIMPs)特异性抑制。生理状态下,ECM处于不断产生和不断降解的动态平衡中,MMPs/TIMPs是影响ECM降解的最主要的一组酶系,本文拟就MMPs/TIMPs与肺纤维化的关系加以综述。 Matrix metalloproteinases (MMPs) are a family of structural and functional homologues of zinc-dependent proteases that specifically degrade the extracellular matrix (ECM) and are expressed by matrix metalloproteinase Inhibitors (tissue inhibitors of metalloproteinases, TIMPs) specific inhibition. In the physiological state, ECM is in the constant dynamic balance of production and degradation, and MMPs / TIMPs are the most important enzyme groups that affect the degradation of ECM. This article reviews the relationship between MMPs / TIMPs and pulmonary fibrosis.