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一、MRSA感染的流行病学1960年合成了新青霉素Ⅰ,用于治疗耐药金葡菌,而翌年便出现了MRSA(耐新青霉素Ⅰ金葡菌)。在日本,作者于1974年从当时流行了2～3年的小儿脓胸中分离出1例MRSA,当时从脓胸分离出的全葡菌,即使对新青霉素Ⅰ不耐药,也对原有的第一代先锋霉素类药物有高度耐药性。这是由于这些葡萄球菌产生的β-内酰胺酶量多的结果,这与今天所说的MRSA对先锋霉素类药物耐药有本质的差别。
First, the epidemiology of MRSA infection in 1960 synthesized a new penicillin Ⅰ, for the treatment of drug-resistant Staphylococcus aureus, and the next year there have been MRSA (resistant to penicillin Ⅰ Staphylococcus aureus). In Japan, the authors isolated one case of MRSA from pediatric empyema, which had prevailed for 2 to 3 years, in 1974. The whole-blood bacterium isolated from empyema at that time was resistant to neopentomycin I, The first generation of pioneermycin drugs are highly resistant. This is due to the large amount of β-lactamase produced by these staphylococci, which is essentially different from what is said by MRSA today to be resistant to cephalosporins.