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microRNA是机体内源性表达的长度为18～25个核苷酸的非编码单链小分子RNA通过完全或不完全互补的方式与靶基因结合并使其mRNA裂解或抑制其蛋白翻译,进而在转录后水平调控靶基因的表达,已经作为基因表达的强力调控因子成为肿瘤领域的研究热点近年来,miR-200家族在上皮来源恶性肿瘤中的表达和功能研究逐渐成为焦点,如研究其在肿瘤细胞增殖、侵袭转移等方面的作用机制和靶点miRNA-200b是miRNA-200家族具有代表性的一员,本文对miRNA-200b结构特点、作用机制及其在多种上皮来源肿瘤中的研究情况进行综述
MicroRNAs are non-coding, single-stranded small RNAs of 18-25 nucleotides in length, which are expressed endogenously in the body and bind to the target gene by complete or incomplete complementarity and cleave mRNA or inhibit its protein translation. In recent years, the expression and function of miR-200 family in epithelial-derived malignancies has become the focus of attention, such as the study of its role in the tumor The mechanism and target of miRNA-200b is a representative member of miRNA-200 family. In this paper, the structural characteristics of miRNA-200b, its mechanism of action and its role in various epithelial tumors For review