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目的:探讨TCT检测在早期子宫颈癌及癌前病变初筛中的临床应用价值。方法:回顾性分析2005~2008年2 235例宫颈新柏氏TCT检查结果,TCT检查异常者行阴道镜、并阴道镜指导下活组织检查,以组织病理学为金标准。将细胞学结果与组织病理学结果对照,评价TCT检测在子宫颈病变中的诊断价值。结果:2 235例TCT检测结果中,阳性者278例,检出率为12.4%,包括不典型鳞状上皮细胞(AScus)83例(29.9%)、AGcus 6例(2.2%)、低度鳞状上皮内病变(LSIL)140例(50.4%)、高度鳞状上皮内病变(HSIL)43例(14.7%)、鳞状细胞癌(scc)6例(0.22%)。其中AScus或AGcus中CIN占30.34%,LSIL中CIN占85.0%,HSIL中全部病例均为CIN(其中CIN2-3占93.0%)。结论:TCT技术应用于宫颈病变与筛查,可明显提高标本的满意度,配合阴道镜下多点活组织病理检查,能极大提高宫颈癌前病变及宫颈癌的检出率,是宫颈病变筛查的有效方法。
Objective: To investigate the clinical value of TCT detection in the early screening of cervical cancer and precancerous lesions. Methods: A retrospective analysis of 2 235 cases of Cervical TCT from 2005 to 2008, TCT abnormalities underwent colposcopy and colposcopy guided by biopsy, with histopathology as the gold standard. The cytological results and histopathological results were compared to evaluate the diagnostic value of TCT in cervical lesions. Results: Among 2 235 cases of TCT, 278 cases were positive, the detection rate was 12.4%, including 83 cases (29.9%) of AScus, 6 cases of AGcus (2.2%), There were 140 cases (50.4%) of LSIL, 43 cases (14.7%) of high grade squamous intraepithelial lesion (HSIL) and 6 cases (0.22%) of squamous cell carcinoma (SCC). Among them, CIN accounted for 30.34% in AScus or AGcus, 85.0% in LSIL, and CIN in all cases in HSIL (93.0% in CIN2-3). Conclusion: The TCT technique applied to cervical lesions and screening can significantly improve the satisfaction of specimens, with multi-point biopsy under colposcopy pathology can greatly improve the detection rate of cervical precancerous lesions and cervical cancer is cervical lesions Effective method of screening.