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作者采用脂肪乳剂对家兔连续灌胃２ｗ，分析比较了灌胃前后血清甘油三酯（ＴＧ）、总胆固醇（ＴＣ）、载脂蛋自Ｂ（ＡｐｏＢ）之变化和血浆血栓素（ＴＸ２）和前列腺素１６─Ｋｅｔｏ─ＰＧＦ１α之变化。结果发现：ＴＣ、ＴＧ、ＡｐｏＢ、ＴＸＢ２均明显上升，有极显著性差异（Ｐ＜０．０１）；６－Ｋｅｔ－ＰＧＦ１α明显下降，具有极显著性差异（Ｐ＜０．０１）。其中，Ｔｃ含量较灌胃前增力１５．４倍，ＴＧ较灌胃前增加３．３涪，完全符合食饮性动物高脂血症模型的特点。作者采用上述模型观察了灵芝对其ＴＣ、ＴＧ、ＡｐｏＢ、ＴＸＢ２、ｄ－Ｋｅｔｏ－ＰＧＦ１α之影响。结果发现：用灵芝制剂对高脂血症家兔行灌胃治疗，ＴＣ下降率为３．１１８％±２．８９％，ＴＧ下降卒为６２．９９±１２．１８，与对照组有显著差异（Ｐ＜０．０５）。ＡｐｏＢ有一定程度降低。
The authors used fat emulsion to continuously inoculate rabbits for 2 weeks. The changes of serum triglyceride (TG), total cholesterol (TC), apolipoprotein B (ApoB) Changes in Prostaglandin 16-Keto-PGF1α. The results showed that the levels of TC, TG, ApoB and TXB2 were significantly increased (P <0.01), while the levels of 6-Ket-PGF1α were significantly decreased (P <0.01). Among them, the content of Tc was 15.4 times higher than that before intragastric administration, and the TG was increased by 3.3% compared with that before intragastric administration, which fully accorded with the characteristics of diet-induced hyperlipidemia model. Using the above model, we observed the effects of Ganoderma lucidum on TC, TG, ApoB, TXB2 and d-Keto-PGF1α. The results showed that: Ganoderma lucidum preparation for rabbits with hyperlipemia gastric gavage treatment, TC decreased 3.118% ± 2.89%, TG decreased the death of 62.99 ± 12.18, and the control group were significantly different (P <0.05). ApoB reduced to some extent.