以 3,4,5 -三甲氧基苯甲酸甲酯为原料 ,用甲醇为溶剂 ,甲醇钠为催化剂 ,与吗啉经脱醇反应合成 N- ( 3,4,5 -三甲氧基苯甲酰基 )吗啉。对反应的一些影响因素包括反应时间、物料配比等进行了研究 ,得到了较好的反应条件 ,并对反应中产生的副产物进行了分析 ,对其产生的原因进行了探讨。 Using 3,4,5 - trimethoxybenzoic acid methyl ester as raw material, methanol as solvent and sodium methoxide as catalyst, dealcoholized with morpholine to synthesize N- (3,4,5 - trimethoxybenzoyl )Morpholine. Some influencing factors on the reaction including reaction time, material ratio and so on were studied, and the better reaction conditions were obtained. The by-products produced in the reaction were analyzed and the reasons were also discussed.