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目的:探讨妊娠期高血压疾病(HDP)患者PLT计数、血清球蛋白与FIB含量的关系。方法:分析97例HDP孕妇(妊娠期高血压21例、轻度子痫前期26例、早发型重度子痫前期24例和晚发型重度子痫前期26例)患者PLT计数、血清球蛋白和FIB含量的检测结果,并与20例正常晚期妊娠孕妇进行比较。结果:早发型重度子痫前期组PLT计数明显减少,与晚发型组和正常晚期妊娠组比较均有统计学差异(P<0.05);血清球蛋白含量明显下降,与正常组比较有统计学差异(P<0.001),FIB含量明显下降,与晚发型组比较有统计学差异(P<0.05)。结论:早发型重度子痫前期患者血清球蛋白含量下降可能与FIB水平下降有关,而FIB水平下降与PLT计数下降有关,提示早发型重度子痫前期患者凝血功能失代偿。
Objective: To investigate the relationship between PLT count, serum globulin and FIB content in patients with gestational hypertension (HDP). Methods: The PLT count, serum globulin and FIB in 97 HDP pregnant women (21 cases of gestational hypertension, 26 cases of mild preeclampsia, 24 cases of early-onset severe preeclampsia and 26 cases of late-onset severe preeclampsia) were analyzed. Content of the test results, and with 20 cases of normal late pregnancy pregnant women were compared. Results: The PLT counts of early-onset severe preeclampsia group were significantly decreased (P <0.05), and the levels of serum globulin were significantly decreased compared with those of late-onset group and normal late pregnancy group (P <0.001), FIB content decreased significantly compared with late-onset group (P <0.05). CONCLUSION: The decrease of serum globulin in early-onset severe preeclampsia may be related to the decrease of FIB level. The decrease of FIB level is related to the decrease of PLT count, suggesting that coagulation function is decompensated in patients with early-onset severe preeclampsia.