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多年来我們在生产水溶性針剂时,經常发現注射用水和葡萄糖、氯化鈉、复方氯化鈉等注射液經陶质砂芯过滤后,药液的pH值有不同程度的上升,再經加热灭菌后,其pH值复又下降,5%葡萄糖溶液及注射用水有时甚至产生白色渾浊現象,而氯化鈉及复方氯化鈉注射液产生白色渾浊程度更較严重。我們为了查明原因,找出改进措施,对几种砂芯作了如下对比实驗。
Over the years we are in the production of water-soluble injections, it is often found that water for injection and glucose, sodium chloride, compound sodium chloride and other injection by the ceramic sand filter, the pH value of the liquid in varying degrees of increase, and then After heat sterilization, its pH value decreased again, 5% glucose solution and water for injection sometimes even white turbidity phenomenon, and sodium chloride and compound sodium chloride injection white turbidity even more serious. In order to find out the reasons, we find out the improvement measures, and made the following comparative experiments on several sand cores.