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氧哌嗪青霉素(Piperacillin)是一种新型半合成青霉素,在体内可有效对抗需氧和厌氧细菌。在浓度为25微克/毫升时,在对抗假单孢菌属、变形杆菌属、克雷伯氏菌属、沙雷氏菌属和脆弱拟杆菌方面,较羧苄青霉素(Carbenicillin)和羧噻吩青霉素(Ticarcillin)更为有效。在青霉素复合物测试中发现,它对假单孢菌属最具活性,其中包括耐羧苄青霉素菌株。氧哌嗪青霉素在浓度为25微克/毫升时的抗脆弱拟杆菌的活性与噻吩甲氧头孢菌素(Cefoxitin)相当。
Piperacillin is a novel semi-synthetic penicillin that is effective against aerobic and anaerobic bacteria in the body. In the concentration of 25 micrograms / ml, in the fight against Pseudomonas, Proteus, Klebsiella, Serratia bacteria and Bacteroides fragilis, compared with carbenicillin and carcaseicillin (Ticarcillin) is more effective. It was found to be most active against Pseudomonas in the penicillin complex test, including the resistance to carbenicillin. The activity of piperacillin against B. fragilis at a concentration of 25 μg / ml was comparable to that of cefoxitin.