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为加深对弓形虫病发病机理和病变特点的了解，用RH株、B36株和Fukaya株三种弓形虫株分别感染小鼠，用组织学和免疫组化方法对感染后各脏器病变进行系统观察，并着重对早期改变进行分析和比较。结果表明三种虫株引起的改变在病变程度和范围上有所不同，但无质的差异。病变程度可能与虫株在宿主内的繁殖能力有关。
In order to deepen the understanding of the pathogenesis and pathological features of toxoplasmosis, mice were respectively infected with three Toxoplasma gondii strains of RH strain, B36 strain and Fukaya strain. The histological and immunohistochemical methods were used to systematically analyze the pathological changes of various organs after infection Observations, with emphasis on early changes were analyzed and compared. The results showed that the three strains caused by changes in the extent and extent of lesions vary, but no qualitative differences. The extent of the lesion may be related to the reproductive capacity of the insect strain in the host.