地尔硫(Diltiazem)是一种新型钙拮抗剂,广泛用于抗心律失常、心绞痛、高血压等病的治疗,作用明显,毒副作用少。在用药过程中,常与其他药物合并应用。为此,现将其药物相互作用综述如下。一、地尔硫(艹卓)与强心甙有人报道,通过24例健康受试者的药代动力学的研究证明,二者合用时,地尔硫(艹卓)可提高血清地戈辛的浓度,药—时间曲线下面积(AUC)每小时从41增加至58ng/ml,生物半衰期(t(1/2))延长21%,全身清除率减 Diltiazem is a new type of calcium antagonist, which is widely used in the treatment of anti-arrhythmia, angina, hypertension and other diseases with obvious effects and few side effects. In the course of medication, often combined with other drugs. To this end, now the drug interactions are summarized below. A, diltiazem (艹 Zhuo) and cardiac glycosides It was reported through the 24 healthy subjects pharmacokinetic studies have shown that the combination of the two, diltiazem (艹 Zhuo) can increase the serum Geoxin (AUC) increased from 41 to 58 ng / ml per hour, the biological half-life (t (1/2)) was prolonged by 21%, and the systemic clearance rate was reduced by