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目的探讨尿微量白蛋白在早期糖尿病肾病中的应用。方法回顾分析120例患者的临床资料。结果 60例糖尿病患者中尿MA阳性20例,而正常对照组中尿MA阳性0例,两组比较差异有统计学意义(P<0.005),随着糖尿病病程的延长,尿MA阳性率不断上升。结论糖尿病的早期阶段,尿白蛋白的增加及肾小球率过滤率的增加,经治疗可逆转,可以延迟蛋白尿及肾衰的发展,提高生命质量。因此尿微量白蛋白检测对糖尿病肾病的早期诊断具有重要意义。尽早发现肾病,采取相应治疗措施并积极有效地控制血糖,对于有效延缓DN的进展,起着关键作用。临床蛋白尿期出现前如能发现早期肾损伤的症状,采取措施,积极防治可延缓或阻止其进入临床蛋白尿期,从而抑制病情进展,延缓病情。
Objective To investigate the application of urinary microalbumin in early diabetic nephropathy. Methods The clinical data of 120 patients were retrospectively analyzed. Results Urine MA was positive in 20 of 60 diabetics and 0 in urine of normal controls. There was a significant difference between the two groups (P <0.005). With the prolongation of diabetes, the positive rate of urinary MA increased . Conclusion In the early stage of diabetes mellitus, the increase of urinary albumin and the increase of glomerular filtration rate can be retreated after treatment, which can delay the development of proteinuria and renal failure and improve the quality of life. Therefore, urine microalbumin test for the early diagnosis of diabetic nephropathy is of great significance. Early detection of nephropathy, take appropriate treatment measures and actively and effectively control blood sugar, for the effective delay in the progress of DN plays a key role. Clinical proteinuria should be found before the onset of symptoms of early kidney damage, to take measures to prevent or prevent active prevention and treatment of proteinuria into the clinical period, thereby inhibiting the progression of the disease, delay the disease.