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应用高压液相色谱法测定了6例结肠癌病人术中瘤段肠腔灌注5—FU(5—氟尿嘧啶)后门静脉系和周缘静脉血药浓度的动态变化及癌组织与癌旁正常组织中的浓度,结果表明,门静脉系5—FU的浓度显著高于周缘静脉,且维持时间较长,癌组织中5—FU浓度明显高于癌旁正常组织。提示作为大肠癌的术中化疗5—FU瘤段肠腔灌注应是简便安全有效的途径,同理,5—FU保留灌肠也应是防治大肠癌局部复发和肝转移的简便合理的给药途径。
The dynamic changes of plasma concentration of 5-FU (5-fluorouracil) in the portal vein and peripheral venous blood in patients with colorectal cancer were measured by high pressure liquid chromatography and the tumor tissue and adjacent normal tissues were measured. The concentration showed that the concentration of 5-FU in the portal vein was significantly higher than that in the peripheral vein, and the duration of maintenance was longer. The concentration of 5-FU in the cancer tissue was significantly higher than that in the adjacent normal tissue. It is suggested that 5-FU intraluminal perfusion of colorectal cancer should be a simple, safe, and effective way for intraoperative chemotherapy. Similarly, 5-FU retention enema should also be a simple and reasonable route of administration to prevent local recurrence and hepatic metastasis of colorectal cancer. .