孤雌胚胎干细胞(p ESCs)是建立患者特异性多能干细胞的有效途径,因具有类似胚胎干细胞(ESCs)自我复制和多潜能特性,成为再生医学的“种子细胞”。杂合型p ESCs有望用于自体移植,纯合型p ESCs理论上可用于异体基因疗法,却因自然杀伤(NK)细胞识别而产生免疫排斥反应。本文旨在综述孤雌生殖的表观遗传特性,总结p ESCs在细胞疗法中的优势和局限性,阐述克服免疫排斥反应的新策略。 Parthenogenetic embryonic stem cells (p ESCs) are an effective way to establish patient-specific pluripotent stem cells and become “seed cells” of regenerative medicine due to their self-replication and multipotency characteristics similar to that of embryonic stem cells (ESCs). Heterozygous p-ESCs are expected to be used in autologous transplantation. Homozygous p-ESCs can theoretically be used for allogeneic gene therapy, but immune rejection occurs due to natural killer (NK) cell recognition. This article aims to summarize the epigenetic characteristics of parthenogenesis, summarize the advantages and limitations of p ESCs in cell therapy, and elucidate new strategies to overcome immunological rejection.